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Chapters
- 00:05Title
- 00:51Preparation of Samples and NMR Instrument for 19F TD-NMR Measurement
- 01:56Measurement of the T1 or Longitudinal Relaxation Time for Standard Pure API Samples
- 03:23Measuring Calibration Samples with Pure API
- 04:29Measuring Drug Product Samples as Tablets
- 04:59Generation of Calibration Curves with Pure API Samples and Adding the Data from Drug Product Samples as Tablets in the Calibration Curve
- 06:59Calculation of the Fluorinated API Drug Weight in the Formulated Drug Product Using the Calibration Curves
- 07:33Results: Evaluation of the Average Drug Content of Cinacalcet in Tablet Dosage Forms by Low-field Fluorine-19 Time-domain Nuclear Magnetic Resonance
- 08:29Conclusion
Une technique simple et non destructive qui mesure la teneur moyenne des substances médicamenteuses dans les produits formulés contenant du fluor à l’aide de champ faible fluor-19 (19F) domaine temporel (TD) résonance magnétique (RMN) est présentée ici. La technique peut être appliquée pour le développement et la fabrication de médicaments dans l’industrie pharmaceutique.
