While infiltrating macrophages are continuously recruited to adult tissues from circulating precursors, resident macrophages seed their tissue during development, where they are maintained without further input from progenitors. The progenitors for resident macrophages were recently identified. Here, we present methods for the genetic fate mapping of the resident macrophage progenitors.
Iturri, L., Saenz Coronilla, J., Lallemand, Y., Gomez Perdiguero, E. Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry. J. Vis. Exp. (125), e55305, doi:10.3791/55305 (2017).