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August 14, 2016
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To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.
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Sajadi, A., Provost, C., Pham, B., Brouillette, J. Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps. J. Vis. Exp. (114), e54215, doi:10.3791/54215 (2016).
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