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Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
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Medicine
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JoVE Journal Medicine
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

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9,035 Views

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10:19 min

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August 14, 2016

DOI:

10.3791/54215-v

DOI:
10.3791/54215-v

•

10:19 min
August 14, 2016

•

8 Views
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1Department of Pharmacology,Université de Montréal, 2Department of Neuroscience,Université de Montréal, 3Hôpital du Sacré-coeur de Montréal Research Center,Université de Montréal

Summary

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To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

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Sajadi, A., Provost, C., Pham, B., Brouillette, J. Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps. J. Vis. Exp. (114), e54215, doi:10.3791/54215 (2016).

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