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Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

English

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17,696 Views

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12:40 min

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April 06, 2015

DOI:

10.3791/52412-v

DOI:
10.3791/52412-v

•

12:40 min
April 06, 2015

•

9 Views
, , , , , , ,
1Institute of Immunology and Infection Research,University of Edinburgh, 2Manchester Collaborative Centre for Inflammation Research

Summary

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Heligmosomoides polygyrus is a murine nematode with powerful immunomodulatory capabilities that closely resemble those of highly-prevalent human helminth infection. Here we describe a protocol for the long-term maintenance of the H. polygyrus lifecycle.

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Heligmosomoides PolygyrusNematospiroides DubiusH. BakeriGastrointestinal HelminthImmunomodulatoryChronic InfectionMiceHelminth-derived Immune RegulationAllergyAutoimmunityL3 LarvaeAdult ParasitesExcretory-secretory ProductsHES

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Johnston, C. J. C., Robertson, E., Harcus, Y., Grainger, J. R., Coakley, G., Smyth, D. J., McSorley, H. J., Maizels, R. Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products. J. Vis. Exp. (98), e52412, doi:10.3791/52412 (2015).

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