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August 06, 2014
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De novo mutations in the male germline may contribute to adverse health outcomes in subsequent generations. Here we describe a protocol for the use of a transgenic rodent model for quantifying mutations in male germ cells induced by environmental agents.
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O'Brien, J. M., Beal, M. A., Gingerich, J. D., Soper, L., Douglas, G. R., Yauk, C. L., Marchetti, F. Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency. J. Vis. Exp. (90), e51576, doi:10.3791/51576 (2014).
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