This content is Free Access.
22,830 Views
•
07:13 min
•
March 26, 2014
DOI:
1Tumor Microenvironment and Metastasis Program,Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine,University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics,Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine,University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center,University of Pennsylvania, 6Center for Advanced Medicine,University of Pennsylvania
Summary
Automatically generated
臨床的に関連する転移性乳癌における乳管系の結果へのアデノウイルス-Creを持つ潜在変異の活性化。 YFPプロモーターの組み込みは、遠位の転移性腫瘍細胞の追跡を可能にする。このモデルは、潜在性転移、抗腫瘍免疫、および乳癌を治療するための新規な免疫療法を設計するための研究に有用である。
Read Article
Cite this Article
Rutkowski, M. R., Allegrezza, M. J., Svoronos, N., Tesone, A. J., Stephen, T. L., Perales-Puchalt, A., Nguyen, J., Zhang, P. J., Fiering, S. N., Tchou, J., Conejo-Garcia, J. R. Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer. J. Vis. Exp. (85), e51171, doi:10.3791/51171 (2014).
Copy