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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
JoVE Journal
Medicine
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JoVE Journal Medicine
An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

English

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34,454 Views

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06:48 min

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September 18, 2013

DOI:

10.3791/50873-v

DOI:
10.3791/50873-v

•

06:48 min
September 18, 2013

•

15 Views
, ,
1Department of Medicine,Northwestern University, 2Robert H. Lurie Cancer Center,Northwestern University, 3Center for Molecular Innovation and Drug Discovery,Northwestern University

Summary

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This orthotopic model of human prostate cancer allows for quantification of tumor size, circulating tumor cells, and formation of distinct metastasis to the lung. As cells must escape the primary organ, enter the blood stream, and implant into a secondary site, this model effectively recapitulates the scenario in humans.

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Cite this Article

Pavese, J., Ogden, I. M., Bergan, R. C. An Orthotopic Murine Model of Human Prostate Cancer Metastasis. J. Vis. Exp. (79), e50873, doi:10.3791/50873 (2013).

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