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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
JoVE Journal
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

34,396 Views

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06:48 min

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September 18, 2013

DOI:

10.3791/50873-v

DOI:
10.3791/50873-v

•

06:48 min
September 18, 2013

•

15 Views
, ,
1Tıp Fakültesi,Northwestern University, 2Robert H. Lurie Cancer Center,Northwestern University, 3Center for Molecular Innovation and Drug Discovery,Northwestern University

Özet

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This orthotopic model of human prostate cancer allows for quantification of tumor size, circulating tumor cells, and formation of distinct metastasis to the lung. As cells must escape the primary organ, enter the blood stream, and implant into a secondary site, this model effectively recapitulates the scenario in humans.

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Cite this Article

Pavese, J., Ogden, I. M., Bergan, R. C. An Orthotopic Murine Model of Human Prostate Cancer Metastasis. J. Vis. Exp. (79), e50873, doi:10.3791/50873 (2013).

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