/
/
Двойной Tracer ПЭТ-МРТ протокол для количественного измерения регионального мозга энергетических субстратов Поглощение в Крысы
A subscription to JoVE is required to view this content. Sign in or start your free trial.
6,943 Views
•
15:10 min
•
December 28, 2013
DOI:
1Research Center on Aging and Department of Physiology and Biophysics,Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center,Université de Sherbrooke, 3Department of Computer Science,Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology,Université de Sherbrooke
Summary
Automatically generated
Small-animal positron emission tomography enables the assessment of the brain's two main energy substrates: glucose and ketones. In the present method, 11C-acetoacetate and 18F-fluorodeoxyglucose are injected sequentially in each animal, and their uptake is measured quantitatively in specific brain regions determined from the magnetic resonance images.
Read Article
Cite this Article
Roy, M., Nugent, S., Tremblay, S., Descoteaux, M., Beaudoin, J., Tremblay, L., Lecomte, R., Cunnane, S. C. A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat. J. Vis. Exp. (82), e50761, doi:10.3791/50761 (2013).
Copy