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A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
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A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
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December 28, 2013
DOI:
1Research Center on Aging and Department of Physiology and Biophysics,Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center,Université de Sherbrooke, 3Department of Computer Science,Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology,Université de Sherbrooke
Summary
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Small-animal positron emission tomography enables the assessment of the brain's two main energy substrates: glucose and ketones. In the present method, 11C-acetoacetate and 18F-fluorodeoxyglucose are injected sequentially in each animal, and their uptake is measured quantitatively in specific brain regions determined from the magnetic resonance images.
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Roy, M., Nugent, S., Tremblay, S., Descoteaux, M., Beaudoin, J., Tremblay, L., Lecomte, R., Cunnane, S. C. A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat. J. Vis. Exp. (82), e50761, doi:10.3791/50761 (2013).
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