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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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November 19, 2012
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Summary
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A multi-faceted approach to investigating functional changes to hippocampal circuitry is explained. Electrophysiological techniques are described along with the injury protocol, behavioral testing and regional dissection method. The combination of these techniques can be applied in similar fashion for other brain regions and scientific questions.
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InvestigationsAlterationsHippocampal Circuit FunctionMild Traumatic Brain InjuryTBINeurological ImpairmentsMemory DeficitsSeizure ThresholdHippocampal DysfunctionLateral Fluid Percussion InjuryAnimal ModelNeuronal Cell LossGliosisIonic PerturbationCombinatorial MethodEx Vivo Physiological TechniquesAnimal Behavior AnalysisBiochemical AnalysisCognitive DisabilityExtracellular Field Potential RecordingWhole-cell Patch-clampingVoltage Sensitive Dye RecordingRegionally Dissecting Subregions Of The HippocampusNeurochemical AnalysisMetabolic Analysis
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Smith, C. J., Johnson, B. N., Elkind, J. A., See, J. M., Xiong, G., Cohen, A. S. Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury. J. Vis. Exp. (69), e4411, doi:10.3791/4411 (2012).
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