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Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
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July 12, 2012
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A technique is described for broadly opening the blood-brain barrier in the mouse using microbubbles and ultrasound. Using this technique, manganese can be administered to the mouse brain. Because manganese is an MRI contrast agent that accumulates in depolarized neurons, this approach enables imaging of neuronal activity.
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Functional NeuroimagingUltrasonic Blood-brain Barrier DisruptionManganese-enhanced MRIMiceGenetic And Molecular Underpinnings Of NeuroscienceAIM MRINeuronal Activity MappingMn2+Calcium AnalogMRI EnhancementMn2+ ClearanceBlood-brain Barrier (BBB)UltrasoundGas-filled MicrobubblesUltrasound Contrast AgentsBBB Opening MethodPerflutren Microbubbles
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Howles, G. P., Qi, Y., Rosenzweig, S. J., Nightingale, K. R., Johnson, G. A. Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI. J. Vis. Exp. (65), e4055, doi:10.3791/4055 (2012).
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