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Parasite indotta geneticamente Driven Autoimmune Disease Cuore Chagas nel modello di pollo
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July 29, 2012
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L'inoculazione di<em> Trypanosoma cruzi</em> In uova fertili prima incubazione rende il kDNA parassita minicircle integrazione nel genoma delle cellule dell'embrione. Incrocio rivela il trasferimento verticale delle mutazioni alla progenie. Il kDNA integra in regioni codificanti in cromosomi diversi ed i polli morire con una malattia infiammatoria autoimmune cuore.
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Parasite-inducedGenetically-drivenAutoimmuneChagas Heart DiseaseChicken ModelTrypanosoma CruziAcute InfectionsChronic InfectionsChagas DiseaseAutoimmunityParasite PersistenceT. Cruzi InoculationAir ChamberFertilized EggsMature Chicken Immune SystemParasite-free At HatchingParasite Mitochondrial Kinetoplast DNA (kDNA) Minicircle IntegrationTargeted Prime TAIL-PCRSouthern HybridizationsCloningSequencingRuptured Open Reading FramesTranscription FactorsImmune System FactorsPhosphatase (GTPase)Adenylate CyclasePhosphorylases (PKCNF-Kappa B ActivatorPI-3K)MyocarditisRejection Of Target Heart FibersCytotoxic Lymphocytes
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Teixeira, A. R. L., Nitz, N., Bernal, F. M., Hecht, M. M. Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model. J. Vis. Exp. (65), e3716, doi:10.3791/3716 (2012).
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