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Journal / Immunology and Infection / Parasite Induced Genetically Driven Autoimmune…
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Immunology and Infection
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JoVE Journal Immunology and Infection
Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
 

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

Article DOI: 10.3791/3716-v • 09:23 min • July 29th, 2012
July 29th, 2012 •
1, 1, 1, 1
1Chagas Disease Multidisciplinary Research Laboratory, University of Brasilia

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The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.

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Parasite-induced Genetically-driven Autoimmune Chagas Heart Disease Chicken Model Trypanosoma Cruzi Acute Infections Chronic Infections Chagas Disease Autoimmunity Parasite Persistence T. Cruzi Inoculation Air Chamber Fertilized Eggs Mature Chicken Immune System Parasite-free At Hatching Parasite Mitochondrial Kinetoplast DNA (kDNA) Minicircle Integration Targeted Prime TAIL-PCR Southern Hybridizations Cloning Sequencing Ruptured Open Reading Frames Transcription Factors Immune System Factors Phosphatase (GTPase) Adenylate Cyclase Phosphorylases (PKC NF-Kappa B Activator PI-3K) Myocarditis Rejection Of Target Heart Fibers Cytotoxic Lymphocytes
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