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Immunology and Infection
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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Immunology and Infection
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JoVE Journal Immunology and Infection
Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

English

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15,544 Views

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10:29 min

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August 29, 2012

DOI:

10.3791/3697-v

DOI:
10.3791/3697-v

•

10:29 min
August 29, 2012

•

1 Views
,
1Department of Surgery,The Ohio State University Medical Center

Summary

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Murine bone marrow transplantation is a widely used technique to study immunological mechanisms governing graft-versus-host disease in humans. The ability to monitor T cell trafficking patterns in vivo allows for detailed analysis of the development and perpetuation of T cell responses during graft-versus-host disease.

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Anthony, B. A., Hadley, G. A. Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model. J. Vis. Exp. (66), e3697, doi:10.3791/3697 (2012).

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