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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Immunology and Infection
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JoVE Journal Immunology and Infection
Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

English

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21,802 Views

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11:36 min

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April 21, 2012

DOI:

10.3791/3533-v

DOI:
10.3791/3533-v

•

11:36 min
April 21, 2012

•

7 Views
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1Program for the Study and Control of Tropical Diseases -PECET-School of Medicine,University of Antioquia, 2School of Agrarian Sciences,University of Antioquia

Summary

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Optimization of the experimental hamster model for cutaneous leishmaniasis by intradermal injection of Leishmania promastigotes at the dorsal skin. This approach is useful during inoculation, follow-up, characterization of lesions, application of treatments and obtaining of clinical samples. Locomotion, search for food and water, play and social activities are preserved.

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Cutaneous LeishmaniasisDorsal SkinHamstersScreeningAntileishmanial DrugsInoculationUlcerLesion Size MeasurementHamster Model OptimizationGolden HamstersIntradermal InjectionPromastigotesLeishmania SpeciesProgression Of LesionsInfection EvaluationChronic LesionsClinical EvolutionIndurationsUlcersTreatment ApplicationClinical Samples

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Robledo, S. M., Carrillo, L. M., Daza, A., Restrepo, A. M., Muñoz, D. L., Tobón, J., Murillo, J. D., López, A., Ríos, C., Mesa, C. V., Upegui, Y. A., Valencia-Tobón, A., Mondragón-Shem, K., RodrÍguez, B., Vélez, I. D. Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs. J. Vis. Exp. (62), e3533, doi:10.3791/3533 (2012).

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