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免疫不全マウスにおけるヒト網膜芽細胞腫の腫瘍の確立と伝播

JoVE Journal
Medicine

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JoVE Journal Medicine

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

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免疫不全マウスにおけるヒト網膜芽細胞腫の腫瘍の確立と伝播

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07:55 min

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August 04, 2011

DOI:

DOI:

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07:55 min

August 04, 2011

•

9 Views

Wesley S. Bond^1,2, Lalita Wadhwa^2,3, Laszlo Perlaky^2,3, Rebecca L. Penland⁴, Mary Y. Hurwitz^2,3, Richard L. Hurwitz*^2,3,5,6, Patricia Chèvez-Barrios*^4,5,7

¹Interdepartmental Program in Translational Biology & Molecular Medicine,Baylor College of Medicine, ²Texas Children's Cancer Center,Baylor College of Medicine, ³Department of Pediatrics,Baylor College of Medicine, ⁴Department of Pathology,The Methodist Hospital Research Institute, ⁵Department of Ophthalmology,Retinoblastoma Center of Houston, ⁶Baylor College of Medicine,Center for Cell and Gene Therapy, ⁷Center for Cell and Gene Therapy,Baylor College of Medicine

Summary

メソッドは、マウスにヒトの網膜芽細胞腫の腫瘍を伝播するために記述されています。腫瘍細胞は、直接免疫欠損マウスの眼に注入されています。二次腫瘍が正常に直接ヒト腫瘍および培養tumorspheresから採取した細胞の両方を使用して確立されている。

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