This content is Free Access.
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
3,737 Views
•
11:06 min
•
January 31, 2022
DOI:
Özet
Automatically generated
Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.
Read Article
Cite this Article
Novac, O., Silva, R., Young, L., Lachani, K., Hughes, D., Kostrzewski, T. Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro. J. Vis. Exp. (179), e63389, doi:10.3791/63389 (2022).
Copy