Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.
Novac, O., Silva, R., Young, L., Lachani, K., Hughes, D., Kostrzewski, T. Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro. J. Vis. Exp. (179), e63389, doi:10.3791/63389 (2022).