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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
JoVE Revista
Biología
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JoVE Revista Biología
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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11:06 min

January 31, 2022

DOI:

11:06 min
January 31, 2022

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Summary

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Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.

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