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Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy
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JoVE Journal Nörobilim
Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

2,100 Views

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09:29 min

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August 17, 2021

DOI:

10.3791/62929-v

DOI:
10.3791/62929-v

•

09:29 min
August 17, 2021

•

7 Views
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1Department of Pharmacology,University of Virginia, 2UVA Brain Institute,University of Virginia

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This report describes the methods to generate a model of temporal lobe epilepsy based on the electrical kindling of transgenic VGAT-Cre mice. Kindled VGAT-Cre mice may be useful in determining what causes epilepsy and for screening novel therapies.

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Straub, J., Vitko, I., Gaykema, R. P., Perez-Reyes, E. Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy. J. Vis. Exp. (174), e62929, doi:10.3791/62929 (2021).

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