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Neuroscience

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JoVE Journal Neuroscience
Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy
 

Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

Article DOI: 10.3791/62929-v • 09:29 min • August 17th, 2021
August 17th, 2021 •
1, 1, 1, 1,2
1Department of Pharmacology, University of Virginia, 2UVA Brain Institute, University of Virginia

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Summary
Automatic Translation

This report describes the methods to generate a model of temporal lobe epilepsy based on the electrical kindling of transgenic VGAT-Cre mice. Kindled VGAT-Cre mice may be useful in determining what causes epilepsy and for screening novel therapies.

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Preparation Implantation Electrodes Electrically Kindling VGAT-Cre Mice Model Temporal Lobe Epilepsy Seizures Mechanisms Epileptogenesis Therapies Headsets Polytetrafluoroethylene-coated Stainless Steel Wire Insulation Coat Pins Flux Solder
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