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Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
JoVE Journal
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JoVE Journal İmmünoloji ve Enfeksiyon
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

6,367 Views

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07:25 min

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September 25, 2019

DOI:

10.3791/60043-v

DOI:
10.3791/60043-v

•

07:25 min
September 25, 2019

•

15 Views
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1Department of Microbial Pathogenesis and Immunology,Texas A&M University Health Science Center, 2Department of Ophthalmology,Harvard Tıp Fakültesi

Özet

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Presented here is a protocol for the effective suppression of hepatitis B virus (HBV) replication in mice by utilizing adoptive cell transfer (ACT) of stem cell-derived viral antigen (Ag)-specific T lymphocytes. This procedure may be adapted for potential ACT-based immunotherapy of HBV infection.

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Stem CellViral Antigen-specific T LymphocytesHBV ReplicationIPSC-derived T CellsAdoptive Cell TransferT Cell ReceptorHBV PlasmidHydrodynamic DeliveryCD8-positive T Cells

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Cite this Article

Xiong, X., Lei, F., Haque, M., Song, J. Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice. J. Vis. Exp. (151), e60043, doi:10.3791/60043 (2019).

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