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Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
JoVE Journal
Biyokimya
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JoVE Journal Biyokimya
Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

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00:15 min

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September 28, 2019

DOI:

10.3791/59883-v

DOI:
10.3791/59883-v

•

00:15 min
September 28, 2019

•

4 Views
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1Department of Biological Sciences,Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran

Özet

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Provided here is a protocol for investigating the interactions between native form, prefibrillar, and mature amyloid fibrils of different peptides and proteins with mitochondria isolated from different tissues and various areas of the brain.

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MitochondriaAmyloid FibrilsAlpha-synucleinMembrane PermeabilizationNeurodegenerative DiseasesBrainIsolationHomogenizationCentrifugationDensity GradientMyelinMitochondrial Fraction

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Cite this Article

Zadali, R., Ghareghozloo, E. R., Ramezani, M., Hassani, V., Rafiei, Y., Chiyaneh, S. M., Meratan, A. A. Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils. J. Vis. Exp. (151), e59883, doi:10.3791/59883 (2019).

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