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Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat
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JoVE Journal Nörobilim
Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat

Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat

9,173 Views

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06:44 min

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June 26, 2019

DOI:

10.3791/59738-v

DOI:
10.3791/59738-v

•

06:44 min
June 26, 2019

•

16 Views
,
1Department of Neurosciences, Faculté de Médecine,Université de Montréal, 2Hôpital du Sacré-Cœur de Montréal, 3Groupe de Recherche sur le Système Nerveux Central (GRSNC),Université de Montréal

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The rat thoracic spinal hemisection is a valuable and reproducible model of unilateral spinal cord injury to investigate the neural mechanisms of locomotor recovery and treatment efficacy. This article includes a detailed step-by-step guide to perform the hemisection procedure and to assess locomotor performance in an open-field arena.

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Brown, A. R., Martinez, M. Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat. J. Vis. Exp. (148), e59738, doi:10.3791/59738 (2019).

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