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Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
JoVE Journal
İmmünoloji ve Enfeksiyon
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JoVE Journal İmmünoloji ve Enfeksiyon
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

8,783 Views

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07:20 min

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November 28, 2018

DOI:

10.3791/58643-v

DOI:
10.3791/58643-v

•

07:20 min
November 28, 2018

•

4 Views
, , , , , ,
1Centre for Misfolding Diseases, Department of Chemistry,University of Cambridge, 2European Research Institute for the Biology of Aging,University Medical Centre Groningen

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We describe protocols for using the wide field-of-view nematode tracking platform (WF-NTP), which enables high-throughput phenotypic characterization of large populations of Caenorhabditis elegans. These protocols can be used to characterize subtle behavioral changes in mutant strains or in response to pharmacological treatment in a highly scalable fashion.

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Perni, M., Casford, S., Aprile, F. A., Nollen, E. A., Knowles, T. P., Vendruscolo, M., Dobson, C. M. Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. J. Vis. Exp. (141), e58643, doi:10.3791/58643 (2018).

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