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Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
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JoVE Journal Nörobilim
Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

7,804 Views

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06:23 min

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October 30, 2018

DOI:

10.3791/58229-v

DOI:
10.3791/58229-v

•

06:23 min
October 30, 2018

•

1 Views
1Division of Neuromedical Science, Institute of Natural Medicine,University of Toyama

Özet

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Here a protocol to investigate the early effects of amyloid-β (Aβ) in the brain is presented. This shows that Aβ induces clathrin-mediated endocytosis and collapse of axonal growth cones. The protocol is useful in studying early effects of Aβ on axonal growth cones and may facilitate prevention of Alzheimer's disease.

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Cite this Article

Kuboyama, T. Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons. J. Vis. Exp. (140), e58229, doi:10.3791/58229 (2018).

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