需要订阅 JoVE 才能查看此. 登录或开始免费试用。
Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
7,804 Views
•
06:23 min
•
October 30, 2018
DOI:
Summary
Automatically generated
Here a protocol to investigate the early effects of amyloid-β (Aβ) in the brain is presented. This shows that Aβ induces clathrin-mediated endocytosis and collapse of axonal growth cones. The protocol is useful in studying early effects of Aβ on axonal growth cones and may facilitate prevention of Alzheimer's disease.
Read Article
Cite this Article
Kuboyama, T. Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons. J. Vis. Exp. (140), e58229, doi:10.3791/58229 (2018).
Copy