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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

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07:02 min

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February 11, 2019

DOI:

10.3791/56569-v

DOI:
10.3791/56569-v

•

07:02 min
February 11, 2019

•

4 Views
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1Centre for Human Drug Research (CHDR), Leiden

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A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.

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PharmacodynamicCentral Nervous SystemCholinergic DrugsEarly Phase Drug DevelopmentNeuropsychologicalNeurophysiologicalTest BatteryRepeated MeasurementsConcentration Effects RelationshipsDose EscalationComputerized TestEye ElectrodesEEGSubject Performance

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Hart, E. P., Alvarez-Jimenez, R., Davidse, E., Doll, R. J., Cohen, A. F., Van Gerven, J. M., Groeneveld, G. J. A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development. J. Vis. Exp. (144), e56569, doi:10.3791/56569 (2019).

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