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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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February 11, 2019
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A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.
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Hart, E. P., Alvarez-Jimenez, R., Davidse, E., Doll, R. J., Cohen, A. F., Van Gerven, J. M., Groeneveld, G. J. A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development. J. Vis. Exp. (144), e56569, doi:10.3791/56569 (2019).
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