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大鼠电癫痫发作与海马的分离检测突触后密度蛋白的变化
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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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大鼠电癫痫发作与海马的分离检测突触后密度蛋白的变化

11,693 Views

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09:07 min

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August 15, 2017

DOI:

10.3791/56016-v

DOI:
10.3791/56016-v

•

09:07 min
August 15, 2017

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13 Views
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1Department of Molecular and Integrative Physiology,University of Illinois at Urbana-Champaign, 2Neuroscience Program,University of Illinois at Urbana-Champaign

Özet

Automatically generated

电癫痫 (ECS) 是一种电治疗严重抑郁症的实验动物模型。ECS 全球刺激海马活动, 导致突和突触可塑性。在这里, 我们描述的方法的 ECS 诱导大鼠和亚细胞分型的海马, 以检查癫痫诱导的变化, 突触蛋白。

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Electroconvulsive SeizureHippocampusPostsynaptic Density ProteinsNeuroplasticityPulse GeneratorSeizure InductionRacine ScaleHippocampal Fractionation

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Jang, S., Jeong, H. G., Chung, H. J. Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins. J. Vis. Exp. (126), e56016, doi:10.3791/56016 (2017).

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