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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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JoVE Journal 神経科学
Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

11,693 Views

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09:07 min

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August 15, 2017

DOI:

10.3791/56016-v

DOI:
10.3791/56016-v

•

09:07 min
August 15, 2017

•

13 Views
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1Department of Molecular and Integrative Physiology,University of Illinois at Urbana-Champaign, 2Neuroscience Program,University of Illinois at Urbana-Champaign

概要

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Electroconvulsive seizure (ECS) is an experimental animal model of electroconvulsive therapy for severe depression. ECS globally stimulates activity in the hippocampus, leading to synaptogenesis and synaptic plasticity. Here, we describe methods for ECS induction in rats and for subcellular fractionation of their hippocampi to examine seizure-induced changes in synaptic proteins.

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Jang, S., Jeong, H. G., Chung, H. J. Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins. J. Vis. Exp. (126), e56016, doi:10.3791/56016 (2017).

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