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Optogenetic Random Mutagenesis Using Histone-miniSOG in C. elegans
JoVE Journal
Genetik
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JoVE Journal Genetik
Optogenetic Random Mutagenesis Using Histone-miniSOG in C. elegans

Optogenetic Random Mutagenesis Using Histone-miniSOG in C. elegans

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04:51 min

November 14, 2016

DOI:

04:51 min
November 14, 2016

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Özet

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Genetically-encoded histone-miniSOG induces genome-wide heritable mutations in a blue light-dependent manner. This mutagenesis method is simple, fast, free of toxic chemicals, and well-suited for forward genetic screening and transgene integration.

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