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Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2
JoVE Journal
Kanser Araştırmaları
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JoVE Journal Kanser Araştırmaları
Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2

7,824 Views

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09:13 min

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October 24, 2016

DOI:

10.3791/54633-v

DOI:
10.3791/54633-v

•

09:13 min
October 24, 2016

•

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1Department of Applied Biochemistry,Institute of Biotechnology, Berlin University of Technology, 2Department of Medical Biotechnology,Institute of Biotechnology, Berlin University of Technology, 3Department of Bioprocess Engineering,Institute of Biotechnology, Berlin University of Technology

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The recellularized extracellular matrix of a decellularized rat liver can be used as a humanized, three-dimensional ex vivo model to study the distribution and transgene expression of a virus or viral vector.

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Hiller, T., Röhrs, V., Dehne, E., Wagner, A., Fechner, H., Lauster, R., Kurreck, J. Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2. J. Vis. Exp. (116), e54633, doi:10.3791/54633 (2016).

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