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Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays
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November 10, 2016
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Peptide adsorption to plasticware during traditional tip-based serial dilutions can significantly impact potency determination and confound the understanding of structure-activity relationships used for lead identification and lead optimization phases of drug discovery. Here methods for automated acoustic non-contact serial dilution of peptide samples are described.
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Naylor, J., Rossi, A., Brankin, C., Hornigold, D. C. Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays. J. Vis. Exp. (117), e54542, doi:10.3791/54542 (2016).
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