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Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
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JoVE Journal Nörobilim
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

17,726 Views

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08:16 min

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June 17, 2015

DOI:

10.3791/52805-v

DOI:
10.3791/52805-v

•

08:16 min
June 17, 2015

•

30 Views
, , , ,
1Department of Pathology and Cell Biology,Columbia University Medical Center, 2The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain,Columbia University Medical Center, 3Department of Neurology,Columbia University Medical Center

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Here, we present a protocol for direct stereotaxic brain infusion of amyloid-beta. This methodology provides an alternative in vivo mouse model to address the short-term effects of amyloid-beta on brain neurons.

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Cite this Article

Jean, Y. Y., Baleriola, J., Fà, M., Hengst, U., Troy, C. M. Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus. J. Vis. Exp. (100), e52805, doi:10.3791/52805 (2015).

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