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Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
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神经科学
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JoVE 杂志 神经科学
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

17,744 Views

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08:16 min

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June 17, 2015

DOI:

10.3791/52805-v

DOI:
10.3791/52805-v

•

08:16 min
June 17, 2015

•

30 Views
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1Department of Pathology and Cell Biology,Columbia University Medical Center, 2The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain,Columbia University Medical Center, 3Department of Neurology,Columbia University Medical Center

Summary

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Here, we present a protocol for direct stereotaxic brain infusion of amyloid-beta. This methodology provides an alternative in vivo mouse model to address the short-term effects of amyloid-beta on brain neurons.

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Cite this Article

Jean, Y. Y., Baleriola, J., Fà, M., Hengst, U., Troy, C. M. Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus. J. Vis. Exp. (100), e52805, doi:10.3791/52805 (2015).

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