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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

15,757 Views

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10:08 min

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December 02, 2014

DOI:

10.3791/52200-v

DOI:
10.3791/52200-v

•

10:08 min
December 02, 2014

•

11 Views
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1Department of Biomedical Engineering,Johns Hopkins Üniversitesi, 2Department of Anesthesiology and Critical Care Medicine,Johns Hopkins Üniversitesi, 3Department of Medicine (Cardiology),Johns Hopkins Üniversitesi, 4The Australian School of Advanced Medicine,Macquarie University

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We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.

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Cite this Article

Kuo, M. M., Barodka, V., Abraham, T. P., Steppan, J., Shoukas, A. A., Butlin, M., Avolio, A., Berkowitz, D. E., Santhanam, L. Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound. J. Vis. Exp. (94), e52200, doi:10.3791/52200 (2014).

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