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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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Medicina
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JoVE Journal Medicina
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

15,778 Views

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10:08 min

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December 02, 2014

DOI:

10.3791/52200-v

DOI:
10.3791/52200-v

•

10:08 min
December 02, 2014

•

11 Views
, , , , , , , ,
1Department of Biomedical Engineering,Johns Hopkins University, 2Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University, 3Department of Medicine (Cardiology),Johns Hopkins University, 4The Australian School of Advanced Medicine,Macquarie University

Summary

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We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.

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Cite this Article

Kuo, M. M., Barodka, V., Abraham, T. P., Steppan, J., Shoukas, A. A., Butlin, M., Avolio, A., Berkowitz, D. E., Santhanam, L. Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound. J. Vis. Exp. (94), e52200, doi:10.3791/52200 (2014).

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