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Assays for the Identification of Novel Antivirals against Bluetongue Virus
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JoVE Journal İmmünoloji ve Enfeksiyon
Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

13,805 Views

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12:02 min

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October 11, 2013

DOI:

10.3791/50820-v

DOI:
10.3791/50820-v

•

12:02 min
October 11, 2013

•

5 Views
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1Division of Infectious Diseases, Department of Medicine,University of Alabama at Birmingham, 2Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry,Auburn University

Özet

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Three assays, including the cytopathic effect (CPE)-based assay, dose-response assay and Time-of-Addition (ToA) assay have been developed, optimized, validated and utilized to identify novel antivirals against Bluetongue virus (BTV), as well as to determine the possible Mechanism-of-Action (MoA) for newly identified antivirals.

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Gu, L., Schneller, S. W., Li, Q. Assays for the Identification of Novel Antivirals against Bluetongue Virus. J. Vis. Exp. (80), e50820, doi:10.3791/50820 (2013).

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