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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Bölümler
- 00:05Başlık
- 02:51Animal Preparation
- 04:53Fluorescence Tomography System Calibration
- 06:15Imaging Protocol
- 08:45Image Reconstruction
- 10:34Results: Fluorescence Reconstruction
- 11:06Conclusion
Diffuse fluorescence tomography offers a relatively low-cost and potentially high-throughout approach to preclinical in vivo tumor imaging. The methodology of optical data collection, calibration, and image reconstruction is presented for a computed tomography-guided non-contact time-domain system using fluorescent targeting of the tumor biomarker epidermal growth factor receptor in a mouse glioma model.
Etiketler
Computed Tomography-guided Time-domain Diffuse Fluorescence TomographySmall AnimalsCancer BiomarkersPreclinical Drug DiscoveryDevelopment StudiesLight AbsorptionOptical Signal PropagationVisible WavelengthsRed And Near-infrared (near-IR) Light AbsorptionNon-elastic ScatteringFluorescent AgentsImaging SystemsLight Propagation ModelsWhole Body Three-dimensional ImagingIll-posed Nature Of Diffuse Fluorescence TomographyStabilityContrast RecoverySpatial ResolutionImage Reconstruction TechniquesFMI In Small AnimalsCharge-coupled Device (CCD)-based SystemsSensitivity Detectors
