This work shows how to form an RNA/DNA hybrid at the chromosomal level and reveal transfer of genetic information from RNA to genomic DNA in yeast cells.
Shen, Y., Storici, F. Generation of RNA/DNA Hybrids in Genomic DNA by Transformation using RNA-containing Oligonucleotides. J. Vis. Exp. (45), e2152, doi:10.3791/2152 (2010).