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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Química
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JoVE Journal Química
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

1,822 Views

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11:27 min

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August 09, 2022

DOI:

10.3791/63993-v

DOI:
10.3791/63993-v

•

11:27 min
August 09, 2022

•

1 Views
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1Research Center Pharmaceutical Engineering,GmbH, 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy,University of Graz

Summary

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This publication shows the application of x-ray diffraction and differential scanning calorimetry as gold standards for investigating the solid-state of lipid-based excipients (LBEs). Understanding the solid-state alteration in LBEs and its effect on the performance of pharmaceutical products thereof is the key factor for manufacturing robust lipid-based dosage forms.

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Salar-Behzadi, S., Corzo, C., Laggner, P. A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients. J. Vis. Exp. (186), e63993, doi:10.3791/63993 (2022).

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