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用于量化生长因子介导的整合素力学和附着力的张力计系绳探头
JoVE Journal
Biologia
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JoVE Journal Biologia
Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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用于量化生长因子介导的整合素力学和附着力的张力计系绳探头

2,204 Views

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09:56 min

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February 11, 2022

DOI:

10.3791/63529-v

DOI:
10.3791/63529-v

•

09:56 min
February 11, 2022

•

4 Views
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1Department of Cell, Developmental, and Integrative Biology,University of Alabama at Birmingham

Summary

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TGT表面是研究生长因子整合素串扰的创新平台。灵活的探针设计、粘附配体的特异性以及刺激条件的精确调节，可以对EGFR-整合素相互作用进行可靠的定量评估。结果突出了EGFR作为“机械组织者”调谐整合机制，影响焦点粘附组装和细胞扩散。

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Cite this Article

Rao, T. C., Mattheyses, A. L. Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion. J. Vis. Exp. (180), e63529, doi:10.3791/63529 (2022).

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