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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Neurociência
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JoVE Journal Neurociência
Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

5,742 Views

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07:14 min

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February 25, 2022

DOI:

10.3791/62932-v

DOI:
10.3791/62932-v

•

07:14 min
February 25, 2022

•

3 Views
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1Department of Chemical Biology,Tokyo Medical University, 2Division of Molecular and Developmental Biology,National Institute of Genetics, 3Department of Genetics,Graduate University for Advanced Studies (SOKENDAI)

Summary

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We describe a protocol to induce phase transition of TAR DNA-binding protein 43 (TDP-43) by light in the spinal motor neurons using zebrafish as a model.

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Cite this Article

Asakawa, K., Handa, H., Kawakami, K. Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae. J. Vis. Exp. (180), e62932, doi:10.3791/62932 (2022).

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