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En adfærdsmæssig skærm for varmeinducerede anfald i musemodeller af epilepsi
JoVE Journal
Neurociência
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JoVE Journal Neurociência
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

En adfærdsmæssig skærm for varmeinducerede anfald i musemodeller af epilepsi

DOI:
10.3791/62846-v

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06:58 min

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July 12, 2021

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, ,
1Department of Developmental and Cell Biology,University of California, 2Department of Anatomy and Neurobiology,University of California

Capítulos

  • 00:04Introduction
  • 01:06Preparation for the Heat-Induced Seizure Assay
  • 02:36Heat-Induced Seizure Assay
  • 04:36Results: Screening for Occurrence of Heat-Induced Seizures in Mice with the Different Genetic Backgrounds
  • 06:17Conclusion

Summary

Tadução automática

Tadução automática

Målet med metoden er at screene for hypertermi eller varmeinducerede anfald i musemodeller. Protokollen beskriver brugen af et specialbygget kammer med kontinuerlig overvågning af kropstemperaturen for at afgøre, om forhøjet kropstemperatur fører til anfald.

Tags

Keywords: Heat-induced SeizuresGEFS+ MutationsFebrile SeizuresDigital Temperature ControllerHeating BoxBody TemperaturePotential TherapiesRectal Temperature ProbeAnesthesiaScreening AssayBody WeightRecovery CageCore Body TemperatureHeat ChamberTemperature Gradient

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