Journal
/
神经科学
/
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
JoVE 杂志
神经科学
This content is Free Access.
JoVE 杂志 神经科学
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

4,259 Views

•

06:58 min

•

July 12, 2021

DOI:

10.3791/62846-v

DOI:
10.3791/62846-v

•

06:58 min
July 12, 2021

•

11 Views
, ,
1Department of Developmental and Cell Biology,University of California, 2Department of Anatomy and Neurobiology,University of California

Summary

Automatically generated

The goal of the method is to screen for hyperthermia or heat-induced seizures in mouse models. The protocol describes the use of a custom-built chamber with continuous monitoring of the body temperature to determine whether elevated body temperature leads to seizures.

Explore More Videos

Heat-induced SeizuresGEFS+ MutationsFebrile SeizuresDigital Temperature ControllerHeating BoxBody TemperaturePotential TherapiesRectal Temperature ProbeAnesthesiaScreening AssayBody WeightRecovery CageCore Body TemperatureHeat ChamberTemperature Gradient

Read Article

Cite this Article

Das, A., Smith, M. A., O'Dowd, D. K. A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy. J. Vis. Exp. (173), e62846, doi:10.3791/62846 (2021).

Download .ris file

Copy

Share Video

.

Copy