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A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
JoVE Journal
Neurociência
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JoVE Journal Neurociência
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

DOI:
10.3791/62846-v

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06:58 min

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July 12, 2021

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, ,
1Department of Developmental and Cell Biology,University of California, 2Department of Anatomy and Neurobiology,University of California

Capítulos

  • 00:04Introduction
  • 01:06Preparation for the Heat-Induced Seizure Assay
  • 02:36Heat-Induced Seizure Assay
  • 04:36Results: Screening for Occurrence of Heat-Induced Seizures in Mice with the Different Genetic Backgrounds
  • 06:17Conclusion

Summary

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Tadução automática

The goal of the method is to screen for hyperthermia or heat-induced seizures in mouse models. The protocol describes the use of a custom-built chamber with continuous monitoring of the body temperature to determine whether elevated body temperature leads to seizures.

Tags

Keywords: Heat-induced SeizuresGEFS+ MutationsFebrile SeizuresDigital Temperature ControllerHeating BoxBody TemperaturePotential TherapiesRectal Temperature ProbeAnesthesiaScreening AssayBody WeightRecovery CageCore Body TemperatureHeat ChamberTemperature Gradient

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