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联合药物输液和电生理学的显微注射系统

JoVE Journal
Neurociência

This content is Free Access.

JoVE Journal Neurociência

Microinjectrode System for Combined Drug Infusion and Electrophysiology

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联合药物输液和电生理学的显微注射系统

DOI:

10.3791/60365-v

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08:30 min

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November 13, 2019

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M. Isabel Vanegas, Kenneth R. Hubbard², Rahim Esfandyarpour⁴, Behrad Noudoost

¹Department of Ophthalmology and Visual Sciences,University of Utah, ²Department of Biomedical Engineering,University of Utah, ³Department of Electrical Engineering and Computer Science,University of California, Irvine, ⁴Department of Biomedical Engineering,University of California, Irvine

Capítulos

00:04Título
00:46Construction of the Microinjectrode for Stimulation and Recording
02:21Microfluidic System
03:22Preparation of the Microfluidic System
05:46Performing Recording for an Infusion Experiment
06:38Results: Memory Guided Saccade Task during Muscimol Infusion in FEF (Frontal Eye Field)
07:26Conclusion

Summary

Tadução automática

我们提出了一个显微注射系统，用于电生理学和辅助交付实验探头（即纳米传感器，微电极），可选配药物输注。广泛可用的微流体成分与包含探头的导管耦合。包括一个微注射的分步协议，在猴皮层中注入木糖醇时的结果。

Tags

Keywords: Microinjectrode System Drug Infusion Electrophysiology Microelectrodes Nanosensors Awake Behaving Animals Microfluidic Infusion Nanoliter Scale Cannula T Junction Capillary Tubing Gold Pin Epoxy Glue Three-way Valves Microfluidic Circuit

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