Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

Abha K. Rajbhandari; Sarah T. Gonzalez; Michael S. Fanselow

doi:10.3791/58306

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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

JoVE Journal
Comportamento

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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

11,675 Views

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05:49 min

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October 13, 2018

DOI:

10.3791/58306-v

DOI:

10.3791/58306-v

•

05:49 min

October 13, 2018

•

6 Views

Abha K. Rajbhandari^1,2, Sarah T. Gonzalez^1,2, Michael S. Fanselow^1,2,3

¹Department of Psychology,University of California, Los Angeles, ²Staglin Center for Brain and Behavioral Health,University of California, Los Angeles, ³Department of Psychiatry and Biobehavioral Sciences,University of California, Los Angeles

Summary

Here we describe the detailed methodology required to conduct stress-enhanced fear learning (SEFL) experiments, a preclinical model of post-traumatic stress disorder, in both rats and mice. The model utilizes aspects of Pavlovian fear conditioning and freezing as an index of enhanced fear in rodents.

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Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder

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